3 papers
cs.CE2025
Physicochemically Informed Dual-Conditioned Generative Model of T-Cell Receptor Variable Regions for Cellular Therapy
Jiahao Ma, Hongzong Li, Ye-Fan Hu +1
Physicochemically informed biological sequence generation has the potential to accelerate computer-aided cellular therapy, yet current models fail to \emph{jointly} ensure novelty,…
cs.LG2025
ABConformer: Physics-inspired Sliding Attention for Antibody-Antigen Interface Prediction
Zhang-Yu You, Jiahao Ma, Hongzong Li +2
Accurate prediction of antibody-antigen (Ab-Ag) interfaces is critical for vaccine design, immunodiagnostics, and therapeutic antibody development. However, achieving reliable pred…
cs.LG2025
CAME-AB: Cross-Modality Attention with Mixture-of-Experts for Antibody Binding Site Prediction
Hongzong Li, Jiahao Ma, Zhanpeng Shi +5
Antibody binding site prediction plays a pivotal role in computational immunology and therapeutic antibody design. Existing sequence or structure methods rely on single-view featur…