409 citations · 2.8k across the 41 of their papers we have counts for
36 papers · 1 filter
Mechanistic bridges from receptors to whole-brain dynamics: mean-field reductions, validity domains, and computational trade-offs
Yannael Bossard, Lehna Bekri, Alain Destexhe
Many pharmacological and pathological perturbations arise at molecular, synaptic, or cellular scales, but are observed through population and whole-brain signals. Cross-scale reduc…
Neuronal cable equations derived from the hydrodynamic motion of charged particles
Davide Forcella, Alberto Romagnoni, Alain Destexhe
Neuronal cable theory is usually derived from an electric analogue of the membrane, which contrasts with the slow movement of ions in aqueous media. We show here that it is possibl…
A formalism for the long-distance magnetic field generated by populations of neurons
Alexis Garcia-Rodriguez, Alain Destexhe
Brain activity can be measured using magnetic fields located at some distance from the brain, a technique called magneto-encephalography (MEG). The origin of such magnetic fields a…
Optimal responsiveness and collective oscillations emerging from the heterogeneity of inhibitory neurons
Matteo di Volo, Alain Destexhe
The brain is characterized by a strong heterogeneity of inhibitory neurons. We report that spiking neural networks display a resonance to the heterogeneity of inhibitory neurons, w…
Is there sufficient evidence for criticality in cortical systems?
Alain Destexhe, Jonathan D. Touboul
Many studies have found evidence that the brain operates at a critical point, a processus known as self-organized criticality. A recent paper found remarkable scalings suggestive o…
The scientific case for brain simulations
Gaute T. Einevoll, Alain Destexhe, Markus Diesmann +7
A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is simulation of large-scale model networks of neurons. Here we argue…
Cholinergic switch between two types of slow waves in cerebral cortex
Trang-Anh E. Nghiem, Núria Tort-Colet, Tomasz Górski +8
Sleep slow waves are known to participate in memory consolidation, yet slow waves occurring under anesthesia present no positive effects on memory. Here, we shed light onto this pa…
State equation from the spectral structure of human brain activity
Trang-Anh Nghiem, Jean-Marc Lina, Matteo di Volo +4
Neural electromagnetic (EM) signals recorded non-invasively from individual human subjects vary in complexity and magnitude. Nonetheless, variation in neural activity has been diff…
Maximum entropy models reveal the excitatory and inhibitory correlation structures in cortical neuronal activity
Trang-Anh Nghiem, Bartosz Telenczuk, Olivier Marre +2
Maximum Entropy models can be inferred from large data-sets to uncover how collective dynamics emerge from local interactions. Here, such models are employed to investigate neurons…
Pairwise Ising model analysis of human cortical neuron recordings
Trang-Anh Nghiem, Olivier Marre, Alain Destexhe +1
During wakefulness and deep sleep brain states, cortical neural networks show a different behavior, with the second characterized by transients of high network activity. To investi…
A mean-field model for conductance-based networks of adaptive exponential integrate-and-fire neurons
Yann Zerlaut, Alain Destexhe
Voltage-sensitive dye imaging (VSDi) has revealed fundamental properties of neocortical processing at mesoscopic scales. Since VSDi signals report the average membrane potential, i…
A framework to reconcile frequency scaling measurements, from intracellular recordings, local-field potentials, up to EEG and MEG signals
Claude Bedard, Jean-Marie Gomes, Thierry Bal +1
In this viewpoint article, we discuss the electric properties of the medium around neurons, which are important to correctly interpret extracellular potentials or electric field ef…
Enhanced responsiveness in asynchronous irregular neuronal networks
Zahara Girones, Alain Destexhe
Networks of excitatory and inhibitory neurons display asynchronous irregular (AI) states, where the activities of the two populations are balanced. At the single cell level, it was…
Intracellular impedance measurements reveal non-ohmic properties of the extracellular medium around neurons
Jean-Marie Gomes, Claude Bedard, Silvana Valtcheva +6
The electrical properties of extracellular space around neurons are important to understand the genesis of extracellular potentials, as well as for localizing neuronal activity fro…
Power-law statistics and universal scaling in the absence of criticality
Jonathan Touboul, Alain Destexhe
Critical states are sometimes identified experimentally through power-law statistics or universal scaling functions. We show here that such features naturally emerge from networks…
Non-stationary filtered shot noise processes and applications to neuronal membranes
Marco Brigham, Alain Destexhe
Filtered shot noise processes have proven to be very effective in modelling the evolution of systems exposed to stochastic shot noise sources, and have been applied to a wide varie…
Dynamic Balance of Excitation and Inhibition in Human and Monkey Neocortex
Nima Dehghani, Adrien Peyrache, Bartosz Telenczuk +5
Balance of excitation and inhibition is a fundamental feature of in vivo network activity and is important for its computations. However, its presence in the neocortex of higher ma…
Generalized cable formalism to calculate the magnetic field of single neurons and neuronal populations
Claude Bedard, Alain Destexhe
Neurons generate magnetic fields which can be recorded with macroscopic techniques such as magneto-encephalography. The theory that accounts for the genesis of neuronal magnetic fi…
Characterization and Compensation of Network-Level Anomalies in Mixed-Signal Neuromorphic Modeling Platforms
Mihai A. Petrovici, Bernhard Vogginger, Paul Müller +9
Advancing the size and complexity of neural network models leads to an ever increasing demand for computational resources for their simulation. Neuromorphic devices offer a number…
Generalized cable theory for neurons in complex and heterogeneous media
Claude Bedard, Alain Destexhe
Cable theory has been developed over the last decades, usually assuming that the extracellular space around membranes is a perfect resistor. However, extracellular media may displa…
Avalanche analysis from multi-electrode ensemble recordings in cat, monkey and human cerebral cortex during wakefulness and sleep
Nima Dehghani, Nicholas G. Hatsopoulos, Zach D. Haga +5
Self-organized critical states are found in many natural systems, from earthquakes to forest fires, they have also been observed in neural systems, particularly, in neuronal cultur…
A generalized theory for current-source density analysis in brain tissue
Claude Bedard, Alain Destexhe
The current-source density (CSD) analysis is a widely used method in brain electrophysiology, but this method rests on a series of assumptions, namely that the surrounding extracel…
A Comprehensive Workflow for General-Purpose Neural Modeling with Highly Configurable Neuromorphic Hardware Systems
Daniel Brüderle, Mihai A. Petrovici, Bernhard Vogginger +31
In this paper we present a methodological framework that meets novel requirements emerging from upcoming types of accelerated and highly configurable neuromorphic hardware systems.…
Comparative power spectral analysis of simultaneous elecroencephalographic and magnetoencephalographic recordings in humans suggests non-resistive extracellular media
Nima Dehghani, Claude Bedard, Sydney S. Cash +2
The resistive or non-resistive nature of the extracellular space in the brain is still debated, and is an important issue for correctly modeling extracellular potentials. Here, we…