14 citations · 27 across the 6 of their papers we have counts for
6 papers
Design of elastic networks with evolutionary optimised long-range communication as mechanical models of allosteric proteins
Holger Flechsig
Allosteric effects are often underlying the activity of proteins and elucidating generic design aspects and functional principles which are unique to allosteric phenomena represent…
Deciphering intrinsic inter-subunit couplings that lead to sequential hydrolysis of F1-ATPase ring
Liqiang Dai, Holger Flechsig, Jin Yu
The rotary sequential hydrolysis of metabolic machine F1-ATPase is a prominent feature to reveal high coordination among multiple chemical sites on the stator F1 ring, which also c…
TALEs from a spring -- superelasticity of Tal effector protein structures
Holger Flechsig
A simple force-probe setup is employed to study the mechanical properties of transcription activator-like effector (TALE) proteins in computer experiments. It is shown that their s…
Nucleotide-induced conformational motions and transmembrane gating dynamics in a bacterial ABC transporter
Holger Flechsig
ATP-binding cassette (ABC) transporters are integral membrane proteins that mediate the exchange of diverse substrates across membranes powered by ATP hydrolysis. We report results…
Computational biology approach to uncover hepatitis C virus helicase operation
Holger Flechsig
Hepatitis C virus helicase is a molecular motor that splits nucleic acid duplex structures during viral replication, therefore representing a promising target for antiviral treatme…
On the spectral gap in Andreev graphs
Holger Flechsig, Sven Gnutzmann
We introduce Andreev scattering (electron-hole conversion at an interface of a normal conductor to a superconductor) at the outer vertices of a quantum star graph and examine its e…