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q-bio.GN2009
On the clustering of rare codons and its effect on translation
Lalit Ponnala
The presence of clusters of rare codons is known to negatively impact the efficiency and accuracy of protein production. In this paper, we demonstrate a statistical method of ident…
q-bio.GN2007
A mechanistic model for +1 frameshifts in eubacteria
Lalit Ponnala, Donald Bitzer, Anne Stomp +1
This work applies the methods of signal processing and the concepts of control system design to model the maintenance and modulation of reading frame in the process of protein synt…