4 papers · 1 filter
Per-event Uncertainty Quantification for Flow Cytometry using Calibration Beads
Prajakta Bedekar, Megan A. Catterton, Matthew DiSalvo +3
Flow cytometry measurements are widely used in diagnostics and medical decision making. Incomplete understanding of sources of measurement uncertainty can make it difficult to dist…
Uncertainty Quantification of Antibody Measurements: Physical Principles and Implications for Standardization
Paul N. Patrone, Lili Wang, Sheng Lin-Gibson +1
Harmonizing serology measurements is critical for identifying reference materials that permit standardization and comparison of results across different diagnostic platforms. Howev…
Analysis of Diagnostics (Part II): Prevalence, Linear Independence, and Unsupervised Learning
Paul N. Patrone, Raquel A. Binder, Catherine S. Forconi +2
This is the second manuscript in a two-part series that uses diagnostic testing to understand the connection between prevalence (i.e. number of elements in a class), uncertainty qu…
Prevalence estimation methods for time-dependent antibody kinetics of infected and vaccinated individuals: a graph-theoretic approach
Prajakta Bedekar, Rayanne A. Luke, Anthony J. Kearsley
Immune events such as infection, vaccination, and a combination of the two result in distinct time-dependent antibody responses in affected individuals. These responses and event p…