35 citations · 36 across the 6 of their papers we have counts for
7 papers
Tracking Intermittent Particles with Self-Learned Visual Features
Raphael Reme, Victor Piriou, Alison Hanson +5
In time-lapse fluorescence imaging, single-particle-tracking is a powerful tool to monitor the dynamics of objects of interest, and extract information about biological processes.…
Narrow escape to small windows on a small ball modeling the viral entry into the cell nucleus
Thibault Lagache, David Holcman
A certain class of viruses replicates inside a cell if they can enter the nucleus through one of many small target pores, before being permanently trapped or degraded. We adopt for…
Stochastic model of endosomal escape of Influenza virus
Thibault Lagache, Christian Sieben, Tim Meyer +2
Influenza viruses enter a cell via endocytosis after binding to the surface. During the endosomal journey, acidification triggers a conformational change of the virus spike protein…
Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery
Carlo Amoruso, Thibault Lagache, David Holcman
Gene delivery of nucleic acid to the cell nucleus is a fundamental step in gene therapy. In this review of modeling drug and gene delivery, we focus on the particular stage of plas…
Quantifying intermittent transport in cell cytoplasm
T. Lagache, D. Holcman
Active cellular transport is a fundamental mechanism for protein and vesicle delivery, cell cycle and molecular degradation. Viruses can hijack the transport system and use it to r…
Effective Motion of a Virus Trafficking Inside a Biological Cell
Thibault Lagache, David Holcman
Virus trafficking is fundamental for infection success and plasmid cytosolic trafficking is a key step of gene delivery. Based on the main physical properties of the cellular trans…