5 papers
Electrochemical DNA Hairpin Sensors for Differentiating Small Molecule Intercalation from Minor Groove Binding
Kiara Thompson, Kian Barnes, Saron Yoseph +5
Small molecule double-stranded DNA intercalators have significant potential for therapeutic applications. However, screening for and confirming a drug candidate's intercalative beh…
Extended electrochemical monitoring of biomolecular binding using commercially available, reusable electrodes in microliter volumes
Jeremy Mendez, Yae Eun Kim, Nafisah Chowdhury +9
Electrochemical biosensors ("E-AB" or "E-DNA" type sensors) that utilize square-wave voltammetry originated in academic labs with a few standard experimental configurations for the…
Modular DNA origami-based electrochemical detection of DNA and proteins
Byoung-jin Jeon, Matteo M. Guareschi, Jaimie M. Stewart +7
The diversity and heterogeneity of biomarkers has made the development of general methods for single-step quantification of analytes difficult. For individual biomarkers, electroch…
Leveraging the Versatility of DNA Origami and Electrochemistry for New Sensing Modalities
Philip S Lukeman
Electrochemical Biosensors are uniquely positioned to offer real-time in vivo molecular sensing due to their robustness to both biofluids and contaminants found in biofluids, and t…
Extending the Operational Lifetime of Nucleic Acid-Based Electrochemical Sensors via Protection Against Competitive Displacement of Oligonucleotides
Vincent Clark, Yuchan Yuan, Frederick Guzman +4
Nucleic acid-based electrochemical sensors (NBEs) have emerged as a promising approach to continuous molecular monitoring in vivo. NBEs consist of electrically conducting gold surf…