10 citations · 18 across the 8 of their papers we have counts for
9 papers
Elucidating the Size of Chemical Space with Assembly Theory
Juan Carlos Morales Parra, Keith Y Patarroyo, Abhishek Sharma +2
Chemical space is unimaginably vast with common heuristic estimates suggesting that there are ca. 10^60 'drug-like' molecules possible below a molecular mass of 500 Da. However, th…
Quantifying the Emergence of Selection Prior to Biological Evolution
Michael Jirasek, Abhishek Sharma, Mary Wong +2
Selection is central to biological evolution, yet there has been no general experimental framework for quantifying selection in chemical systems before life. Here we demonstrate th…
Exploring molecular assembly as a biosignature using mass spectrometry and machine learning
Lindsay A. Rutter, Abhishek Sharma, Ian Seet +3
Molecular assembly offers a promising path to detect life beyond Earth, while minimizing assumptions based on terrestrial life. As mass spectrometers will be central to upcoming So…
Validation of the Scientific Literature via Chemputation Augmented by Large Language Models
Sebastian Pagel, Michael Jirasek, Leroy Cronin
Chemputation is the process of programming chemical robots to do experiments using a universal symbolic language, but the literature can be error prone and hard to read due to ambi…
Mapping Evolution of Molecules Across Biochemistry with Assembly Theory
Sebastian Pagel, Abhishek Sharma, Leroy Cronin
Evolution is often understood through genetic mutations driving changes in an organism's fitness, but there is potential to extend this understanding beyond the genetic code. We pr…
AI-Driven Robotic Crystal Explorer for Rapid Polymorph Identification
Edward C Lee, Daniel Salley, Abhishek Sharma +1
Crystallisation is an important phenomenon which facilitates the purification as well as structural and bulk phase material characterisation using crystallographic methods. However…
Constructing the Molecular Tree of Life using Assembly Theory and Mass Spectrometry
Amit Kahana, Alasdair MacLeod, Hessam Mehr +5
Here we demonstrate the first biochemistry-agnostic approach to map evolutionary relationships at the molecular scale, allowing the construction of phylogenetic models using mass s…
Experimental Measurement of Assembly Indices are Required to Determine The Threshold for Life
Sara I. Walker, Cole Mathis, Stuart Marshall +1
Assembly Theory (AT) was developed to help distinguish living from non-living systems. The theory is simple as it posits that the amount of selection or Assembly is a function of t…
Determining Molecular Complexity using Assembly Theory and Spectroscopy
Michael Jirasek, Abhishek Sharma, Jessica R. Bame +9
Determining the complexity of molecules has important applications from molecular design to understanding the history of the process that led to the formation of the molecule. Curr…