160 citations · 214 across the 3 of their papers we have counts for
4 papers
On the emergence of single versus multi-state allostery
Eric Rouviere, Rama Ranganathan, Olivier Rivoire
Several physical mechanisms have been proposed to explain allostery in proteins. They differ by the number of internal states that they assume a protein to occupy, leaving open the…
The relation between alignment covariance and background-averaged epistasis
Frank J. Poelwijk, Rama Ranganathan
Epistasis, or the context-dependence of the effects of mutations, limits our ability to predict the functional impact of combinations of mutations, and ultimately our ability to pr…
The context-dependence of mutations: a linkage of formalisms
Frank J. Poelwijk, Vinod Krishna, Rama Ranganathan
Defining the extent of epistasis - the non-independence of the effects of mutations - is essential for understanding the relationship of genotype, phenotype, and fitness in biologi…
Rediscovering the power of pairwise interactions
William Bialek, Rama Ranganathan
Two recent streams of work suggest that pairwise interactions may be sufficient to capture the complexity of biological systems ranging from protein structure to networks of neuron…