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cs.CL2026

An Underexplored Frontier: Large Language Models for Rare Disease Patient Education and Communication -- A scoping review

Zaifu Zhan, Yu Hou, Kai Yu +4

Rare diseases affect over 300 million people worldwide and are characterized by complex care pathways, limited clinical expertise, and substantial unmet communication needs through…

cs.CL2026

To Reason or Not to: Selective Chain-of-Thought in Medical Question Answering

Zaifu Zhan, Min Zeng, Shuang Zhou +6

Objective: To improve the efficiency of medical question answering (MedQA) with large language models (LLMs) by avoiding unnecessary reasoning while maintaining accuracy. Methods:…

cs.CL2025

Benchmarking GPT-5 for biomedical natural language processing

Yu Hou, Zaifu Zhan, Min Zeng +3

Biomedical literature and clinical narratives pose multifaceted challenges for natural language understanding, from precise entity extraction and document synthesis to multi-step d…

cs.CL2025

Quantized Large Language Models in Biomedical Natural Language Processing: Evaluation and Recommendation

Zaifu Zhan, Shuang Zhou, Min Zeng +6

Large language models have demonstrated remarkable capabilities in biomedical natural language processing, yet their rapid growth in size and computational requirements present a m…

cs.CL2025

Uncertainty-Aware Large Language Models for Explainable Disease Diagnosis

Shuang Zhou, Jiashuo Wang, Zidu Xu +11

Explainable disease diagnosis, which leverages patient information (e.g., signs and symptoms) and computational models to generate probable diagnoses and reasonings, offers clear c…

cs.CL2025

An evaluation of DeepSeek Models in Biomedical Natural Language Processing

Zaifu Zhan, Shuang Zhou, Huixue Zhou +4

The advancement of Large Language Models (LLMs) has significantly impacted biomedical Natural Language Processing (NLP), enhancing tasks such as named entity recognition, relation…