2 papers
q-bio.BM2024
Multi-variable control to mitigate loads in CRISPRa networks: Extended Version
Krishna Manoj, Theodore W. Grunberg, Domitilla Del Vecchio
The discovery of CRISPR-mediated gene activation (CRISPRa) has transformed the way in which we perform genetic screening, bioproduction and therapeutics through its ability to scal…
q-bio.MN2024
Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action -- Extended Version
M. Ali Al-Radhawi, Krishna Manoj, Dhruv D. Jatkar +3
In the context of epigenetic transformations in cancer metastasis, a puzzling effect was recently discovered, in which the elimination (knock-out) of an activating regulatory eleme…