12 papers
Empirical prior distributions for treatment-by-subgroup interaction heterogeneity in random-effects meta-analysis
Renato Panaro, Christian Röver, Tim Friede
Subgroup analyses are central to the assessment of benefits and risks, where recommendations may depend on evidence that treatment effects differ across patient groups. Valid subgr…
Subgroup analysis in randomized controlled trials with binary outcomes: dilution and logic-respecting properties
Long-Hao Xu, Yang Han, Tim Friede
Subgroup analysis is routinely used in randomized controlled trials to examine whether treatment effects are homogeneous across patient subgroups or differ because of treatment-eff…
Including historical control data in simultaneous inference for pre-clinical multi-arm studies
Max Menssen, Carsten Kneuer, Gyamfi Akyianu +3
In pre- and non-clinical toxicology, the reduction of animal use is highly desireable. Although approaches for possible sample size reduction in the concurrent control group were s…
Bayesian random-effects meta-analysis of aggregate data on clinical events
Christian Röver, Qiong Wu, Anja Loos +1
To investigate intervention effects on rare events, meta-analysis techniques are commonly applied in order to assess the accumulated evidence. When it comes to adverse effects in c…
Blinded sample size re-estimation accounting for uncertainty in mid-trial estimation
Hirotada Maeda, Satoshi Hattori, Tim Friede
For randomized controlled trials to be conclusive, it is important to set the target sample size accurately at the design stage. Comparing two normal populations, the sample size c…
Consistent Bayesian meta-analysis on subgroup specific effects and interactions
Renato Panaro, Christian Röver, Tim Friede
Commonly, clinical trials report effects not only for the full study population but also for patient subgroups. Meta-analyses of subgroup-specific effects and treatment-by-subgroup…