6 papers
Empirical prior distributions for treatment-by-subgroup interaction heterogeneity in random-effects meta-analysis
Renato Panaro, Christian Röver, Tim Friede
Subgroup analyses are central to the assessment of benefits and risks, where recommendations may depend on evidence that treatment effects differ across patient groups. Valid subgr…
Including historical control data in simultaneous inference for pre-clinical multi-arm studies
Max Menssen, Carsten Kneuer, Gyamfi Akyianu +3
In pre- and non-clinical toxicology, the reduction of animal use is highly desireable. Although approaches for possible sample size reduction in the concurrent control group were s…
Consistent Bayesian meta-analysis on subgroup specific effects and interactions
Renato Panaro, Christian Röver, Tim Friede
Commonly, clinical trials report effects not only for the full study population but also for patient subgroups. Meta-analyses of subgroup-specific effects and treatment-by-subgroup…
Utilizing subgroup information in random-effects meta-analysis of few studies
Ao Huang, Christian Röver, Christian Röver +1
Random-effects meta-analyses are widely used for evidence synthesis in medical research. However, conventional methods based on large-sample approximations often exhibit poor perfo…
Subgroup comparisons within and across studies in meta-analysis
Renato Panaro, Christian Röver, Tim Friede
Subgroup-specific meta-analysis synthesizes treatment effects for patient subgroups across randomized trials. Methods include joint or separate modeling of subgroup effects and tre…
A studentized permutation test for the treatment effect in individual participant data meta-analysis
Phuc Thien Tran, Long-Hao Xu, Christian Röver +1
Meta-analysis is a well-established tool used to combine data from several independent studies, each of which usually compares the effect of an experimental treatment with a contro…