4 papers · 1 filter
Deciphering Fingerprints of 3D Molecular Surfaces for Accurate Epitope Prediction
Fang Wu, Weihao Xuan, Jure Leskovec +2
Molecular surfaces encode the geometric and physicochemical patterns that determine antibody-antigen recognition, central to epitope prediction. However, existing methods rely on s…
Position: The Hidden Costs and Measurement Gaps of Reinforcement Learning with Verifiable Rewards
Fang Wu, Aaron Tu, Weihao Xuan +21
Reinforcement learning with verifiable rewards (RLVR) is a practical, scalable way to improve large language models on math, code, and other structured tasks. However, we argue tha…
NoiseRater: Meta-Learned Noise Valuation for Diffusion Model Training
Fang Wu, Haokai Zhao, Da Xing +17
Diffusion models have achieved remarkable success across a wide range of generative tasks, yet their training paradigm largely treats injected noise as uniformly informative. In th…
Proteo-R1: Reasoning Foundation Models for De Novo Protein Design
Fang Wu, Weihao Xuan, Heli Qi +26
Deep learning in de novo protein design has achieved atomic-level fidelity. However, existing models remain largely non-deliberative: they directly synthesize molecular geometries…