312 citations · 1k across the 22 of their papers we have counts for
25 papers
Combining standard chemoradiotherapy with CAR-T cell therapy in malignant gliomas: Insights from an impulsive mathematical framework and virtual trials
Dmitry Sinelshchikov, Nikols Amaru Mora Millán, Miguel Perales-Patón +2
The extreme therapeutic resistance of malignant gliomas motivates the development of multimodal treatment strategies. We present a mechanistic mathematical framework to investigate…
Subthreshold oscillations and spiking in hybrid neuron models with a dynamic threshold
Piotr Bartłomiejczyk, Juan Belmonte-Beitia, Justyna Signerska-Rynkowska
We investigate a class of two-dimensional hybrid non-autonomous periodically forced neuron models known as the Meng-Huguet-Rinzel neuron model, with a dynamic threshold and reset m…
Synergistic interplay of morphology and metabolic activity rule response to CAR-T cells in B-cell lymphomas
Yifan Chen, Soukaina Sabir, Christina Kuttler +13
Cellular immunotherapies are one of the mainstream cancer treatments unveiling the power of the patient's immune system to fight tumors. CAR T-cell therapy, based on genetically en…
Optimizing chemoradiotherapy for malignant gliomas: a validated mathematical approach
Miguel Perales-Patón, Matteo Italia, María Castelló-Pons +4
Malignant gliomas (MGs), particularly glioblastoma, are among the most aggressive brain tumors, with limited treatment options and a poor prognosis. Maximal safe resection and the…
A mathematical model of CAR-T cell therapy in combination with chemotherapy for malignant gliomas
Dmitry Sinelshchikov, Juan Belmonte-Beitia, Matteo Italia
We study the dynamics and interactions between combined chemotherapy and chimeric antigen receptor (CAR-T) cells therapy and malignant gliomas (MG). MG is one of the most common pr…
Understanding the role of B-cells in CAR T-cell therapy in leukemia through a mathematical model
Sergio Serrano, Roberto Barrio, Álvaro Martínez-Rubio +2
Chimeric Antigen Receptor T (CAR-T) cell therapy has been proven to be successful against different leukaemias and lymphomas. This paper makes an analytical and numerical study of…