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q-bio.BM2026
ZeroFold: Protein-RNA Binding Affinity Predictions from Pre-Structural Embeddings
Josef Hanke, Sebastian Pujalte Ojeda, Shengyu Zhang +3
The accurate prediction of protein-RNA binding affinity remains an unsolved problem in structural biology, limiting opportunities in understanding gene regulation and designing RNA…
q-bio.BM2024
PepINVENT: Generative peptide design beyond the natural amino acids
Gökçe Geylan, Jon Paul Janet, Alessandro Tibo +7
Peptides play a crucial role in the drug design and discovery whether as a therapeutic modality or a delivery agent. Non-natural amino acids (NNAAs) have been used to enhance the p…