2 papers
cs.LG2025
A decoupled alignment kernel for peptide membrane permeability predictions
Ali Amirahmadi, Gökçe Geylan, Leonardo De Maria +3
Cyclic peptides are promising modalities for targeting intracellular sites; however, cell-membrane permeability remains a key bottleneck, exacerbated by limited public data and the…
q-bio.BM2024
PepINVENT: Generative peptide design beyond the natural amino acids
Gökçe Geylan, Jon Paul Janet, Alessandro Tibo +7
Peptides play a crucial role in the drug design and discovery whether as a therapeutic modality or a delivery agent. Non-natural amino acids (NNAAs) have been used to enhance the p…