4 papers
Computation of single-cell metabolite distributions using mixture models
Mona K Tonn, Philipp Thomas, Mauricio Barahona +1
Metabolic heterogeneity is widely recognised as the next challenge in our understanding of non-genetic variation. A growing body of evidence suggests that metabolic heterogeneity m…
Opportunities at the interface of network science and metabolic modelling
Varshit Dusad, Denise Thiel, Mauricio Barahona +2
Metabolism plays a central role in cell physiology because it provides the molecular machinery for growth. At the genome-scale, metabolism is made up of thousands of reactions inte…
Prediction of cellular burden with host-circuit models
Evangelos-Marios Nikolados, Andrea Y. Weiße, Diego A. Oyarzún
Heterologous gene expression draws resources from host cells. These resources include vital components to sustain growth and replication, and the resulting cellular burden is a wid…
Optimal metabolic pathway activation
Diego Oyarzún, Brian Ingalls, Richard Middleton +1
This paper deals with temporal enzyme distribution in the activation of biochemical pathways. Pathway activation arises when production of a certain biomolecule is required due to…