4 citations · 10 across the 12 of their papers we have counts for
13 papers
How genome redundancy can promote evolutionary innovation
Domenico Caudo, Mattia Miotto, Giancarlo Ruocco +1
Polyploidy is defined as the existence of more than two complete sets of homologous chromosomes. Despite it being a widespread phenomenon across the tree of life, its role as eithe…
Deciphering the chemical grammar of protein-RNA condensates
Greta Grassmann, Giancarlo Ruocco, Mattia Miotto
Biomolecular phase separation is typically attributed to the polymer physics of long, disordered chains. However, the underlying chemical grammar, i.e. the specific interactions be…
Emergent learning: neuromorphic photonic computing with accelerated training
Sara Peña-Gutiérrez, Giorgio Gosti, Hongsheng Chen +2
Emergent learning transforms a disordered optical medium into a photonic device capable of storage, recognition, and classification of arbitrary memory patterns. First, we show tha…
A mother-machine microfluidic device for non-adherent mammalian cells reveals the population growth strategies
Simone Scalise, Giovanna Peruzzi, Davide Caprini +3
We develop a mother machine-like microfluidic device specifically designed to track the proliferation of T-cells via live-cell microscopy. Although numerous microfluidic setups hav…
Insights into the role of dynamical features in protein complex formation: the case of SARS-CoV-2 spike binding with ACE2
Greta Grassmann, Mattia Miotto, Francesca Alessandrini +4
The functionality of protein-protein complexes is closely tied to the strength of their interactions, making the evaluation of binding affinity a central focus in structural biolog…
Rosette formations as symmetry-breaking events: theory and experiment
Mattia Miotto, Giorgio Gosti, Maria Rosito +6
Multicellular rosettes are observed in different situations such as morphogenesis, wound healing, and cancer progression. While some molecular insights have been gained to explain…
Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies
Mattia Miotto, Giancarlo Ruocco, Matteo Paoluzzi
Eukaryotic cells are characterized by a stiff nucleus whose effect in modeling the collective behavior of cell aggregates is usually underestimated. However, increasing experimenta…
Stochastically Structured Illumination Microscopy scan less super resolution imaging
Denzel Fusco, Emmanouil Xypakis, Ylenia Gigante +5
In Super-resolution, a varying-illumination image stack is required. This enriched the dataset typically necessitates precise mechanical control and micron scale optical alignment…
Robust assessment of asymmetric division in colon cancer cells
Domenico Caudo, Chiara Giannattasio, Simone Scalise +6
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent work suggested that such a mechanism is hijacked by cancer cells to inc…
Probing leukemia cells behavior under starvation
Simone Scalise, Giorgio Gosti, Giancarlo Ruocco +2
The ability of a cancer cell population to achieve heterogeneity in their phenotype distributions offers advantages in tumor invasiveness and drug resistance. Studying the mechanis…
Compact assessment of molecular surface complementarities enhances neural network-aided prediction of key binding residues
Greta Grassmann, Lorenzo Di Rienzo, Giancarlo Ruocco +2
Predicting interactions between biomolecules, such as protein-protein complexes, remains a challenging problem. Despite the many advancements done so far, the performances of docki…
Zepyros: A webserver to evaluate the shape complementarity of protein-protein interfaces
Mattia Miotto, Lorenzo Di Rienzo, Leonardo Bo' +2
Shape complementarity of molecular surfaces at the interfaces is a well-known characteristic of protein-protein binding regions, and it is critical in influencing the stability of…
Evidence of Scaling Regimes in the Hopfield Dynamics of Whole Brain Model
Giorgio Gosti, Sauro Succi, Giancarlo Ruocco
It is shown that a Hopfield recurrent neural network exhibits a scaling regime, whose specific exponents depend on the number of parcels used and the decay length of the coupling s…