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cs.LG2025

Linearized Optimal Transport for Analysis of High-Dimensional Point-Cloud and Single-Cell Data

Tianxiang Wang, Yingtong Ke, Dhananjay Bhaskar +2

Single-cell technologies generate high-dimensional point clouds of cells, enabling detailed characterization of complex patient states and treatment responses. Yet each patient is…

cs.LG2025

STAGED: A Multi-Agent Neural Network for Learning Cellular Interaction Dynamics

Joao F. Rocha, Ke Xu, Xingzhi Sun +6

The advent of single-cell technology has significantly improved our understanding of cellular states and subpopulations in various tissues under normal and diseased conditions by e…

cs.LG2025

Principal Curvatures Estimation with Applications to Single Cell Data

Yanlei Zhang, Lydia Mezrag, Xingzhi Sun +6

The rapidly growing field of single-cell transcriptomic sequencing (scRNAseq) presents challenges for data analysis due to its massive datasets. A common method in manifold learnin…

cs.LG2025

HiPoNet: A Multi-View Simplicial Complex Network for High Dimensional Point-Cloud and Single-Cell Data

Siddharth Viswanath, Hiren Madhu, Dhananjay Bhaskar +7

In this paper, we propose HiPoNet, an end-to-end differentiable neural network for regression, classification, and representation learning on high-dimensional point clouds. Our wor…

cs.LG2024

Exploring the Manifold of Neural Networks Using Diffusion Geometry

Elliott Abel, Andrew J. Steindl, Selma Mazioud +12

Drawing motivation from the manifold hypothesis, which posits that most high-dimensional data lies on or near low-dimensional manifolds, we apply manifold learning to the space of…

cs.LG2024

Latent Representation Learning for Multimodal Brain Activity Translation

Arman Afrasiyabi, Dhananjay Bhaskar, Erica L. Busch +5

Neuroscience employs diverse neuroimaging techniques, each offering distinct insights into brain activity, from electrophysiological recordings such as EEG, which have high tempora…