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Cell strain-stiffening drives cell breakout from embedded spheroids
Shabeeb Ameen, Kyungeun Kim, Ligesh Theeyancheri +5
Understanding how cells escape from embedded spheroids requires a mechanical framework linking stress generation within cells, across cells, and between cells and the surrounding e…
How does an embedded spheroid affect the rigidity of extracellular matrix?
Amanda Parker, J. M. Schwarz
In vitro collagen networks and in silico fiber network models are typically used to represent extracellular matrix in tissues. Such networks exhibit the phenomenon of strain-stiffe…
Enhanced extracellular matrix remodeling due to embedded spheroid fluidization
Tao Zhang, Shabeeb Ameen, Sounok Ghosh +5
Tumor spheroids are in vitro three-dimensional, cellular collectives consisting of cancerous cells. Embedding these spheroids in an in vitro fibrous environment, such as a collagen…
A two-dimensional vertex model for curvy cell-cell interfaces at the subcellular scale
Kyungeun Kim, J. M. Schwarz, Martine Ben Amar
Cross-sections of cell shapes in a tissue monolayer typically resemble a tiling of convex polygons. Yet, examples exist where the polygons are not convex with curved cell-cell inte…