189 citations · 344 across the 9 of their papers we have counts for
10 papers
Geometry and symmetry in biochemical reaction systems
Raffaella Mulas, Rubén J. Sánchez-García, Ben D. MacArthur
Complex systems of intracellular biochemical reactions have a central role in regulating cell identities and functions. Biochemical reaction systems are typically studied using the…
Stability and steady state of complex cooperative systems: a diakoptic approach
Philip Greulich, Benjamin D. MacArthur, Cristina Parigini +1
Cooperative dynamics are common in ecology and population dynamics. However, their commonly high degree of complexity with a large number of coupled degrees of freedom renders them…
Entropy, Ergodicity and Stem Cell Multipotency
Sonya J. Ridden, Hannah H. Chang, Konstantinos C. Zygalakis +1
Populations of mammalian stem cells commonly exhibit considerable cell-cell variability. However, the functional role of this diversity is unclear. Here, we analyze expression fluc…
Genome disorder and breast cancer susceptibility
Conor Smyth, Iva Špakulova, Owen Cotton-Barratt +12
Many common diseases have a complex genetic basis in which large numbers of genetic variations combine with environmental and lifestyle factors to determine risk. However, quantify…
Stochastic model of virus and defective interfering particle spread across mammalian cells with immune response
Neil R. Clark, Karla A. Tapia, Aditi Dandapani +3
Much of the work on modeling the spread of viral infections utilized partial differential equa- tions. Traveling-wave solutions to these PDEs are typically concentrated on velociti…
Microdynamics and Criticality of Adaptive Regulatory Networks
Ben D. MacArthur, Rubén J. Sánchez-García, Avi Ma'ayan
We present a model of adaptive regulatory networks consisting of a simple biologically-motivated rewiring procedure coupled to an elementary stability criterion. The resulting netw…