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20082024
most citedThe impact of deleterious passenger mutations on cancer progression

355 citations · 2k across the 27 of their papers we have counts for

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Showing 2012Show all

5 papers · 1 filter

q-bio.PE2012★ 49 cited

The fate of cooperation during range expansions

Kirill S. Korolev

Cooperation is beneficial for the species as a whole, but, at the level of an individual, defection pays off. Natural selection is then expected to favor defectors and eliminate co…

cond-mat.stat-mech2012★ 49 cited

Radial Domany-Kinzel Models with Mutation and Selection

Maxim O. Lavrentovich, Kirill S. Korolev, David R. Nelson

We study the effect of spatial structure, genetic drift, mutation, and selective pressure on the evolutionary dynamics in a simplified model of asexual organisms colonizing a new t…

q-bio.PE2012★ 355 cited

The impact of deleterious passenger mutations on cancer progression

Christopher D McFarland, Gregory V Kryukov, Shamil Sunyaev +1

Cancer progression is driven by a small number of genetic alterations accumulating in a neoplasm. These few driver alterations reside in a cancer genome alongside tens of thousands…

q-bio.PE2012★ 169 cited

Selective sweeps in growing microbial colonies

Kirill S Korolev, Melanie J I Müller, Nilay Karahan +3

Evolutionary experiments with microbes are a powerful tool to study mutations and natural selection. These experiments, however, are often limited to the well-mixed environments of…

q-bio.PE2012

Supplementary information for "Selective sweeps in growing microbial colonies"

Kirill S Korolev, Melanie J I Müller, Nilay Karahan +3

This is supplementary information for arXiv:1204.4896, which also appeared in Physical Biology 9, 026008 (2012). Main text abstract: Evolutionary experiments with microbes are a po…