4 papers
Amino Acids Stabilizing Effect on Protein and Colloidal Dispersions
Ting Mao, Xufeng Xu, Pamina M. Winkler +7
Despite being used for decades as stabilizers, amino acids (AAs) remain mysterious components of many medical and biological formulations. Hypotheses on their role vary ranging fro…
Liquid-liquid phase separation of proteins is modulated by amino acids in vitro and in vivo by regulating protein-protein interactions
Xufeng Xu, Aleksander A. Rebane, Laura R. Julia +3
Liquid liquid phase separation (LLPS) of proteins is an intracellular process that is widely used by cells for many purposes. In living cells (in vivo), LLPS occurs in complex and…
Amino Acids and Their Biological Derivatives Modulate Protein-Protein Interactions In an Additive Way
Xufeng Xu, Francesco Stellacci
Protein-protein interactions (PPI) differ when measured in test tubes and cells due to the complexity of the intracellular environment. Free amino acids (AAs) and their derivatives…
Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation
Quy Ong, Xufeng Xu, Francesco Stellacci
In concentrated macromolecular dispersions, far-from-ideal intermolecular interactions determine the dispersion behaviors including phase transition, crystallization, and liquid-li…