3 papers
q-bio.GN2008
Understanding Distal Transcriptional Regulation from Sequence Motif, Network Inference and Interactome Perspectives
Arvind Rao, Alfred O. Hero, David J. States +1
Gene regulation in higher eukaryotes involves a complex interplay between the gene proximal promoter and distal genomic elements (such as enhancers) which work in concert to drive…
q-bio.GN2007
Understanding Transcriptional Regulation Using De-novo Sequence Motif Discovery, Network Inference and Interactome Data
Arvind Rao, Alfred O. Hero, David J. States +1
Gene regulation is a complex process involving the role of several genomic elements which work in concert to drive spatio-temporal expression. The experimental characterization of…
q-bio.GN2007
Finding Sequence Features in Tissue-specific Sequences
Arvind Rao, Alfred O. Hero, David J. States +1
The discovery of motifs underlying gene expression is a challenging one. Some of these motifs are known transcription factors, but sequence inspection often provides valuable clues…