150 citations · 318 across the 4 of their papers we have counts for
4 papers
Signal processing in the TGF-beta superfamily ligand-receptor network
Jose M. G. Vilar, Ronald Jansen, Chris Sander
The TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses tha…
DNA looping in gene regulation: from the assembly of macromolecular complexes to the control of transcriptional noise
Jose M. G. Vilar, Leonor Saiz
The formation of DNA loops by proteins and protein complexes that bind at distal DNA sites plays a central role in many cellular processes, such as transcription, recombination, an…
Modeling network dynamics: the lac operon, a case study
J. M. G. Vilar, C. C. Guet, S. Leibler
We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We in…
DNA looping and physical constraints on transcription regulation
Jose M. G. Vilar, Stanislas Leibler
DNA looping participates in transcriptional regulation, for instance, by allowing distal binding sites to act synergistically. Here we study this process and compare different regu…