13 papers
SC-TauPath: A Structural Connectivity Attribution Framework for Mapping Tau Propagation Pathways in Alzheimer's Disease
Jing Zhang, Norman Scheel, Minheng Chen +5
Understanding how structural connections are associated with tau propagation in Alzheimer's disease (AD) remains a central open question, yet existing computational models either r…
Probability-Invariant Random Walk Learning on Gyral Folding-Based Cortical Similarity Networks for Alzheimer's and Lewy Body Dementia Diagnosis
Minheng Chen, Tong Chen, Chao Cao +4
Alzheimer's disease (AD) and Lewy body dementia (LBD) present overlapping clinical features yet require distinct diagnostic strategies. While neuroimaging-based brain network analy…
Community-Level Modeling of Gyral Folding Patterns for Robust and Anatomically Informed Individualized Brain Mapping
Minheng Chen, Tong Chen, Yan Zhuang +5
Cortical folding exhibits substantial inter-individual variability while preserving stable anatomical landmarks that enable fine-scale characterization of cortical organization. Am…
Gyral-Sulcal-Net: An Integrated Network Representation of Brain Folding Patterns
Chao Cao, Tong Chen, Nan Zhao +7
Our brain functions as a complex communication network, and studying it from a network perspective offers valuable insights into its organizational principles and links to cognitiv…
GP-GPT: Large Language Model for Gene-Phenotype Mapping
Yanjun Lyu, Zihao Wu, Lu Zhang +11
Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits a…
Bridging Brain Connectomes and Clinical Reports for Early Alzheimer's Disease Diagnosis
Jing Zhang, Xiaowei Yu, Minheng Chen +8
Integrating brain imaging data with clinical reports offers a valuable opportunity to leverage complementary multimodal information for more effective and timely diagnosis in pract…