3 papers
q-bio.BM2024
ABodyBuilder3: Improved and scalable antibody structure predictions
Henry Kenlay, Frédéric A. Dreyer, Daniel Cutting +2
Accurate prediction of antibody structure is a central task in the design and development of monoclonal antibodies, notably to understand both their developability and their bindin…
q-bio.BM2024
De novo antibody design with SE(3) diffusion
Daniel Cutting, Frédéric A. Dreyer, David Errington +2
We introduce IgDiff, an antibody variable domain diffusion model based on a general protein backbone diffusion framework which was extended to handle multiple chains. Assessing the…
q-bio.QM2024
CESPED: a new benchmark for supervised particle pose estimation in Cryo-EM
Ruben Sanchez-Garcia, Michael Saur, Javier Vargas +2
Cryo-EM is a powerful tool for understanding macromolecular structures, yet current methods for structure reconstruction are slow and computationally demanding. To accelerate resea…