activity
20242026
most citedAceFF: A State-of-the-Art Machine Learning Potential for Small Molecules

1 citations · 1 across the 4 of their papers we have counts for

collaborators

11 papers

cs.IT2026

MiLAC-Aided Beamforming for MIMO Over-the-Air Computation

Yaru Wang, Deyou Zhang, Qingchao Li +2

Over-the-air computation (AirComp) enables low-latency wireless data aggregation, but its accuracy is limited by imperfect signal alignment over fading channels and receiver noise.…

cs.LG2026

Structure-guided molecular design with contrastive 3D protein-ligand learning

Carles Navarro, Philipp Tholke, Gianni de Fabritiis

Structure-based drug discovery faces the dual challenge of accurately capturing 3D protein-ligand interactions while navigating ultra-large chemical spaces to identify syntheticall…

physics.chem-ph2026

Thermodynamics-Informed Accurate pKa Prediction and Protonation State Generation in PlayMolecule AI

Francesco Pesce, Stephen Farr, Gianni de Fabritiis

Accurate prediction of acid dissociation constants (p) and the determination of dominant protonation states is critical in drug discovery, influencing molecular properti…

physics.chem-ph20261 cited

AceFF: A State-of-the-Art Machine Learning Potential for Small Molecules

Stephen E. Farr, Stefan Doerr, Antonio Mirarchi +2

We introduce AceFF, a pre-trained machine learning interatomic potential (MLIP) optimized for small molecule drug discovery. While MLIPs have emerged as efficient alternatives to D…

cs.LG2025

Test-Time Training Scaling Laws for Chemical Exploration in Drug Design

Morgan Thomas, Albert Bou, Gianni De Fabritiis

Chemical Language Models (CLMs) leveraging reinforcement learning (RL) have shown promise in de novo molecular design, yet often suffer from mode collapse, limiting their explorati…

cs.LG2025

REINFORCE-ING Chemical Language Models for Drug Discovery

Morgan Thomas, Albert Bou, Jose Carlos Gómez-Tamayo +3

Chemical language models, combined with reinforcement learning (RL), have shown significant promise to efficiently traverse large chemical spaces for drug discovery. However, the p…