4 papers
Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity
Gengqiang Xie, Chaity Modak, Olalekan H Usman +7
Rotational migration is one specific form of collective cell migration when epithelial cells are confined in a spherical geometry, such as in the epithelial acini. This tissue-leve…
Controlling the morphologies and dynamics in three-dimensional tissues
Rajsekhar Das, Xin Li, Sumit Sinha +1
A number of factors, such as, cell-cell interactions and self-propulsion of cells driven by cytoskeletal forces determine tissue morphologies and dynamics. To explore the interplay…
Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos
Xin Li, Robert J. Huebner, Margot L. K. Williams +4
Cells undergo dramatic morphological changes during embryogenesis, yet how these changes affect the formation of ordered tissues remains elusive. Here, we show that a phase transit…
Proliferation-driven mechanical feedback regulates cell dynamics in growing tissues
Sumit Sinha, Xin Li, Abdul N Malmi-Kakkada +1
Local stresses in a tissue, a collective property, regulate cell division and apoptosis. In turn, cell growth and division induce active stresses in the tissue. As a consequence, t…