4 papers
TSAssistant: A Human-in-the-Loop Agentic Framework for Automated Target Safety Assessment
Xiaochen Zheng, Zhiwen Jiang, David Tokar +5
Target Safety Assessment (TSA) requires systematic integration of genetic, transcriptomic, target homology, pharmacological, and clinical data to evaluate potential safety liabilit…
TAMER: A Test-Time Adaptive MoE-Driven Framework for EHR Representation Learning
Yinghao Zhu, Xiaochen Zheng, Ahmed Allam +1
We propose TAMER, a Test-time Adaptive MoE-driven framework for Electronic Health Record (EHR) Representation learning. TAMER introduces a framework where a Mixture-of-Experts (MoE…
Clustering of Disease Trajectories with Explainable Machine Learning: A Case Study on Postoperative Delirium Phenotypes
Xiaochen Zheng, Manuel Schürch, Xingyu Chen +5
The identification of phenotypes within complex diseases or syndromes is a fundamental component of precision medicine, which aims to adapt healthcare to individual patient charact…
Two-Stage Aggregation with Dynamic Local Attention for Irregular Time Series
Xingyu Chen, Xiaochen Zheng, Amina Mollaysa +3
Irregular multivariate time series data is characterized by varying time intervals between consecutive observations of measured variables/signals (i.e., features) and varying sampl…