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cs.AI2026
From Retrieval to Reasoning: Agentic Mechanism Prediction from Cell Painting Profiles
Jiayuan Chen, Botao Yu, Tianyu Liu +3
Cell Painting is a high-content morphological profiling assay widely used for phenotype-based biological inference, with mechanism of action (MOA) prediction as a central applicati…
cs.CV2026
Intervention-Aware Multiscale Representation Learning from Imaging Phenomics and Perturbation Transcriptomics
Jiayuan Chen, Ruoqi Liu, Zishan Gu +1
Microscopy-based phenotypic profiling is scalable for drug discovery but lacks the mechanistic depth of transcriptomics, which remains costly and scarce. Existing multimodal approa…