activity
20232026
most citedEvaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physics

149 citations · 199 across the 16 of their papers we have counts for

collaborators

18 papers

cs.AI2026

Toward Vibe Medicine: A Self-Evolving Multi-Agent Framework for Clinical Decision Support

Qianxue Zhang, Yiming Ren, Shihuan Qin +18

In recent years, the advances of large language models and autonomous agents have revolutionized the healthcare field, facilitating diagnosis and improving treatment results. Howev…

physics.med-ph2026

Applications of Large Language Models in Radiation Oncology: From Workflow Automation to Clinical Intelligence

Yuzhen Ding, Jason Holmes, Yuexing Hao +12

Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction.…

cs.CV2025

Multimodal Fusion for Sim2real Transfer in Visual Reinforcement Learning

Zichun Xu, Jingdong Zhao, Chenyu Guo +6

Depth information is robust to scene appearance variations and inherently carries 3D spatial details. Thus, a visual backbone based on the vision transformer is proposed to fuse RG…

physics.med-ph2025

Critical review of patient outcome study in head and neck cancer radiotherapy

Jingyuan Chen, Yunze Yang, Chenbin Liu +8

Rapid technological advances in radiation therapy have significantly improved dose delivery and tumor control for head and neck cancers. However, treatment-related toxicities cause…

physics.med-ph2025

Fine-Tuning Open-Source Large Language Models to Improve Their Performance on Radiation Oncology Tasks: A Feasibility Study to Investigate Their Potential Clinical Applications in Radiation Oncology

Peilong Wang, Zhengliang Liu, Yiwei Li +12

Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language models have displayed remarkable cap…

physics.med-ph2024

Enabling Clinical Use of Linear Energy Transfer in Proton Therapy for Head and Neck Cancer -- A Review of Implications for Treatment Planning and Adverse Events Study

Jingyuan Chen, Yunze Yang, Hongying Feng +12

Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while spari…

cs.CL2024★ 22 cited

Evaluation of OpenAI o1: Opportunities and Challenges of AGI

Tianyang Zhong, Zhengliang Liu, Yi Pan +74

This comprehensive study evaluates the performance of OpenAI's o1-preview large language model across a diverse array of complex reasoning tasks, spanning multiple domains, includi…

physics.med-ph2024

Robust Optimization for Spot Scanning Proton Therapy based on Dose-Linear Energy Transfer (LET) Volume Constraints

Jingyuan Chen, Yunze Yang, Hongying Feng +8

Purpose: Historically, spot scanning proton therapy (SSPT) treatment planning utilizes dose volume constraints and linear-energy-transfer (LET) volume constraints separately to bal…

physics.med-ph2024

Fast Monte Carlo Dose Calculation in Proton Therapy

Jason Holmes, Hongying Feng, Lian Zhang +3

This article examines the critical role of fast Monte Carlo dose calculations in advancing proton therapy techniques, particularly in the context of increasing treatment customizat…

cs.CL2024★ 2 cited

The Radiation Oncology NLP Database

Zhengliang Liu, Jason Holmes, Wenxiong Liao +12

We present the Radiation Oncology NLP Database (ROND), the first dedicated Natural Language Processing (NLP) dataset for radiation oncology, an important medical specialty that has…

physics.med-ph2023

Noisy probing dose facilitated dose prediction for pencil beam scanning proton therapy: physics enhances generalizability

Lian Zhang, Jason M. Holmes, Zhengliang Liu +11

Purpose: Prior AI-based dose prediction studies in photon and proton therapy often neglect underlying physics, limiting their generalizability to handle outlier clinical cases, esp…

physics.med-ph2023★ 2 cited

Artificial Intelligence-Facilitated Online Adaptive Proton Therapy Using Pencil Beam Scanning Proton Therapy

Hongying Feng, Jie Shan, Carlos E. Vargas +10

We propose an oAPT workflow that incorporates all these functionalities and validate its clinical implementation feasibility with prostate patients. AI-based auto-segmentation tool…

physics.med-ph2023

Benchmarking a foundation LLM on its ability to re-label structure names in accordance with the AAPM TG-263 report

Jason Holmes, Lian Zhang, Yuzhen Ding +7

Purpose: To introduce the concept of using large language models (LLMs) to re-label structure names in accordance with the American Association of Physicists in Medicine (AAPM) Tas…

physics.med-ph2023

Artificial General Intelligence for Radiation Oncology

Chenbin Liu, Zhengliang Liu, Jason Holmes +14

The emergence of artificial general intelligence (AGI) is transforming radiation oncology. As prominent vanguards of AGI, large language models (LLMs) such as GPT-4 and PaLM 2 can…

physics.med-ph2023★ 11 cited

RadOnc-GPT: A Large Language Model for Radiation Oncology

Zhengliang Liu, Peilong Wang, Yiwei Li +12

This paper presents RadOnc-GPT, a large language model specialized for radiation oncology through advanced tuning methods. RadOnc-GPT was finetuned on a large dataset of radiation…

eess.IV2023★ 13 cited

Segment Anything Model (SAM) for Radiation Oncology

Lian Zhang, Zhengliang Liu, Lu Zhang +10

In this study, we evaluate the performance of the Segment Anything Model (SAM) in clinical radiotherapy. Our results indicate that SAM's 'segment anything' mode can achieve clinica…

physics.med-ph2023

Beam mask and sliding window-facilitated deep learning-based accurate and efficient dose prediction for pencil beam scanning proton therapy

Lian Zhang, Jason M. Holmes, Zhengliang Liu +12

Purpose: To develop a DL-based PBSPT dose prediction workflow with high accuracy and balanced complexity to support on-line adaptive proton therapy clinical decision and subsequent…

physics.med-ph2023★ 149 cited

Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physics

Jason Holmes, Zhengliang Liu, Lian Zhang +8

We present the first study to investigate Large Language Models (LLMs) in answering radiation oncology physics questions. Because popular exams like AP Physics, LSAT, and GRE have…