5 papers
Dose-LET Interactions Predict Capsular Contracture After Proton Postmastectomy Radiation Therapy
Jingyuan Chen, Zeliang Ma, Meiyun Cao +9
Pencil beam scanning (PBS) proton therapy provides highly conformal dose distributions that are increasingly leveraged for postmastectomy radiation therapy (PMRT) to reduce cardiop…
Causal Machine Learning Analysis of Empirical Relative Biological Effectiveness (RBE) for Mandible Osteoradionecrosis in Head and Neck Cancer Radiotherapy
Jingyuan Chen, Zhong Liu, Yunze Yang +8
Mandible Osteoradionecrosis (ORN) is one of the most severe adverse events (AEs) for head and neck (H&N) cancer radiotherapy. Previous retrospective investigations on real-world da…
Critical review of patient outcome study in head and neck cancer radiotherapy
Jingyuan Chen, Yunze Yang, Chenbin Liu +8
Rapid technological advances in radiation therapy have significantly improved dose delivery and tumor control for head and neck cancers. However, treatment-related toxicities cause…
Enabling Clinical Use of Linear Energy Transfer in Proton Therapy for Head and Neck Cancer -- A Review of Implications for Treatment Planning and Adverse Events Study
Jingyuan Chen, Yunze Yang, Hongying Feng +12
Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while spari…
Robust Optimization for Spot Scanning Proton Therapy based on Dose-Linear Energy Transfer (LET) Volume Constraints
Jingyuan Chen, Yunze Yang, Hongying Feng +8
Purpose: Historically, spot scanning proton therapy (SSPT) treatment planning utilizes dose volume constraints and linear-energy-transfer (LET) volume constraints separately to bal…