22 citations · 39 across the 6 of their papers we have counts for
6 papers
Protein abundances and interactions coevolve to promote functional complexes while suppressing non-specific binding
Muyoung Heo, Sergei Maslov, Eugene I. Shakhnovich
How do living cells achieve sufficient abundances of functional protein complexes while minimizing promiscuous non-functional interactions? Here we study this problem using a first…
Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response
Muyoung Heo, Eugene Shakhnovich
Dramatic rise of mutators has been found to accompany adaptation of bacteria in response to many kinds of stress. Two views on the evolutionary origin of this phenomenon emerged: t…
Adaptation through stochastic switching into transient mutators in finite asexual populations
Muyoung Heo, Louis Kang, Eugene Shakhnovich
The importance of mutator clones in the adaptive evolution of asexual populations is not fully understood. Here we address this problem by using an ab initio microscopic model of l…
Emergence of species in evolutionary simulated annealing
Muyoung Heo, Louis Kang, Eugene I. Shakhnovich
Which factors govern the evolution of mutation rates and emergence of species? Here, we address this question using a first principles model of life where population dynamics of as…
Diversity against adversity: How adaptive immunity evolves potent antibodies
Muyoung Heo, Konstantin B. Zeldovich, Eugene I. Shakhnovich
How does immune system evolve functional proteins - potent antibodies - in such a short time? We address this question using a microscopic, protein-level, sequence-based model of h…
Emergence of clonal selection and affinity maturation in an ab initio microscopic model of immunity
Muyoung Heo, Konstantin B. Zeldovich, Eugene I. Shakhnovich
Mechanisms of immunity, and of the host-pathogen interactions in general are among the most fundamental problems of medicine, ecology, and evolution studies. Here, we present a mic…