12 citations · 28 across the 7 of their papers we have counts for
7 papers
Extraction of Deep Phylogenetic Signal and Improved Resolution of Evolutionary Events within the recA/RAD51 Phylogeny
Sree V. Chintapalli, Gaurav Bhardwaj, Jagadish Babu +8
The recA/RAD51 gene family encodes a diverse set of recombinase proteins that effect homologous recombination, DNA-repair, and genome stability. The recA gene family is expressed i…
Towards Solving the Inverse Protein Folding Problem
Yoojin Hong, Kyung Dae Ko, Gaurav Bhardwaj +3
Accurately assigning folds for divergent protein sequences is a major obstacle to structural studies and underlies the inverse protein folding problem. Herein, we outline our theor…
Theories on PHYlogenetic ReconstructioN (PHYRN)
Gaurav Bhardwaj, Zhenhai Zhang, Yoojin Hong +8
The inability to resolve deep node relationships of highly divergent/rapidly evolving protein families is a major factor that stymies evolutionary studies. In this manuscript, we p…
Mapping Complex Networks: Exploring Boolean Modeling of Signal Transduction Pathways
Gaurav Bhardwaj, Christine P. Wells, Reka Albert +2
In this study, we explored the utility of a descriptive and predictive bionetwork model for phospholipase C-coupled calcium signaling pathways, built with non-kinetic experimental…
Brainstorming through the Sequence Universe: Theories on the Protein Problem
Kyung Dae Ko, Yoojin Hong, Gaurav Bhardwaj +3
Just as physicists strive to develop a TOE (theory of everything), which explains and unifies the physical laws of the universe, the life-scientist wishes to uncover the TOE as it…
Adaptive BLASTing through the Sequence Dataspace: Theories on Protein Sequence Embedding
Yoojin Hong, Jaewoo Kang, Dongwon Lee +2
We theorize that phylogenetic profiles provide a quantitative method that can relate the structural and functional properties of proteins, as well as their evolutionary relationshi…