8 citations · 18 across the 6 of their papers we have counts for
6 papers
Cyclooxygenase inhibition in ischemic brain injury
Eduardo Candelario-Jalil, Bernd L. Fiebich
Neuroinflammation is one of the key pathological events involved in the progression of brain damage caused by cerebral ischemia. Metabolism of arachidonic acid through cyclooxygena…
Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat
Eduardo Candelario-Jalil, Saeid Taheri, Yi Yang +5
Increased permeability of the blood-brain barrier (BBB) is important in neurological disorders. Neuroinflammation is associated with increased BBB breakdown and brain injury. Tumor…
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
E. Candelario-Jalil, R. S. Akundi, H. S. Bhatia +5
In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermo…
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
E. Candelario-Jalil, A. Gonzalez-Falcon, M. Garcia-Cabrera +2
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of t…
Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum
E. Candelario-Jalil, H. Slawik, I. Ridelis +4
Prostaglandin E2 (PGE2), is a major prostanoid produced by the activity of cyclooxygenases (COX) in response to various physiological and pathological stimuli. PGE2 exerts its effe…
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
E Candelario-Jalil, A Gonzalez-Falcon, M Garcia-Cabrera +2
Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischaemic brain damage. In the present study, we investigated the effects of selectiv…