2 papers
physics.bio-ph2024
Protein overabundance is driven by growth robustness
H. James Choi, Teresa W. Lo, Kevin J. Cutler +3
Protein expression levels optimize cell fitness: Too low an expression level of essential proteins will slow growth by compromising essential processes; whereas overexpression slow…
q-bio.MN2024
Noise robustness and metabolic load determine the principles of central dogma regulation
Teresa W. Lo, Han James Choi, Dean Huang +1
The processes of gene expression are inherently stochastic, even for essential genes required for growth. How does the cell maximize fitness in light of noise? To answer this quest…