2 papers
stat.ME2024
Comparing restricted mean survival times in small sample clinical trials using pseudo-observations
David Jesse, Cynthia Huber, Tim Friede
The widely used proportional hazard assumption cannot be assessed reliably in small-scale clinical trials and might often in fact be unjustified, e.g. due to delayed treatment effe…
stat.ME2024
Methods for non-proportional hazards in clinical trials: A systematic review
Maximilian Bardo, Cynthia Huber, Norbert Benda +13
For the analysis of time-to-event data, frequently used methods such as the log-rank test or the Cox proportional hazards model are based on the proportional hazards assumption, wh…