2 papers
q-bio.BM2024
Multi-variable control to mitigate loads in CRISPRa networks: Extended Version
Krishna Manoj, Theodore W. Grunberg, Domitilla Del Vecchio
The discovery of CRISPR-mediated gene activation (CRISPRa) has transformed the way in which we perform genetic screening, bioproduction and therapeutics through its ability to scal…
q-bio.QM2024
A Stein's Method Approach to the Linear Noise Approximation for Stationary Distributions of Chemical Reaction Networks
Theodore W. Grunberg, Domitilla Del Vecchio
Stochastic Chemical Reaction Networks are continuous time Markov chain models that describe the time evolution of the molecular counts of species interacting stochastically via dis…