activity
20072014
most citedEvolution of the genetic code from the GC- to the AGUC-alphabet

2 citations · 7 across the 13 of their papers we have counts for

collaborators

13 papers

q-bio.BM2014★ 1 cited

Epigenetic effects of cytosine derivatives are caused by their tautomers in Hoogsteen base pairs

Denis A. Semenov

Deoxycitidine in solution exists as two tautomers one of which is an uncanonical imino one. The latter can dominate with such derivatives as 5-methyl, 5-hydroxymethyl- and 5-formyl…

physics.bio-ph2012

Enol form of uracil in the GU "wobble" pair. NMR evidence

Denis A. Semenov, Vladimir A. Reznikov

GU "wobble" pair may contain either the enol form of uracil and the keto form of guanine or the enol form of guanine and the keto form of uracil. A direct proof of uracil existence…

physics.bio-ph2010

Why is life so exact?

Denis A. Semenov

This is my attempt to answer Schrödinger's question: "What is Life?". In living cell the local combination of atoms is reproduced with incredible accuracy. In the case of protein b…

q-bio.BM2009

From the Wobble to Reliable Hypothesis

Denis A. Semenov

A simple explanation for the symmetry and degeneracy of the genetic code has been suggested. An alternative to the wobble hypothesis has been proposed. This hypothesis offers expla…

q-bio.OT2009

Reasons underlying certain tendencies in the data on the frequency of codon usage

Denis A. Semenov

The tendencies described in this work were revealed in the course of examination of adenine and uracil distribution in the mRNA encoding sequence. The study also discusses the usag…

q-bio.BM2009

What the difference between Thymine and Uracil?

Denis A. Semenov

The wobble hypothesis does not discriminate between uracil and thymine. Methylation could favor further stabilization of uracil in the keto form. Thymine is present in keto form on…