2 citations · 3 across the 3 of their papers we have counts for
4 papers · 1 filter
Inference for Standard Trial Estimands after Data-Driven Subgroup Discovery
Larry F. Leon, Keaven M. Anderson
Data-driven subgroup identification is increasingly used in clinical trials, yet the effect reported for a discovered subgroup is typically the standard analysis: a Cox or generali…
Two-Stage Design with Sample Size Re-estimation Using gsDesign
Keaven M. Anderson, Alison Pedley
The effect size and nuisance parameters needed to appropriately size a clinical trial are generally not adequately understood before a trial begins. Through pre-planned early stopp…
Group Sequential Design for Non-Proportional Hazards: Logrank, Weighted Logrank, and MaxCombo Methods
Yujie Zhao, Yilong Zhang, Larry Leon +1
Non-proportional hazards (NPH) are often observed in clinical trials with time-to-event endpoints. A common example is a long-term clinical trial with a delayed treatment effect in…
Adjusted inference for multiple testing procedure in group sequential designs
Yujie Zhao, Qi Liu, Linda Z. Sun +1
Adjustment of statistical significance levels for repeated analysis in group sequential trials has been understood for some time. Similarly, methods for adjustment accounting for t…