55 citations · 89 across the 7 of their papers we have counts for
7 papers
Unifying Theories in High-Dimensional Biology: Approaches, Challenges and Opportunities
Marianne Bauer, Akshit Goyal, Sidhartha Goyal +19
Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets, including datasets for cells, species, immune systems, neurons and behaviour.…
Phenomenology and dynamics of competitive ecosystems beyond the niche-neutral regimes
Nava Leibovich, Jeremy Rothschild, Sidhartha Goyal +1
Structure, composition and stability of ecological populations are shaped by the inter- and intra-species interactions within these communities. It remains to be fully understood h…
The size of the immune repertoire of bacteria
Serena Bradde, Armita Nourmohammad, Sidhartha Goyal +1
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a…
How adaptive immunity constrains the composition and fate of large bacterial populations
Madeleine Bonsma-Fisher, Dominique Soutiere, Sidhartha Goyal
Features of the CRISPR-Cas system, in which bacteria integrate small segments of phage genome (spacers) into their DNA to neutralize future attacks, suggest that its effect is not…
Rare beneficial mutations can halt Muller's ratchet
Sidhartha Goyal, Daniel J. Balick, Elizabeth R. Jerison +3
The vast majority of mutations are deleterious, and are eliminated by purifying selection. Yet in finite asexual populations, purifying selection cannot completely prevent the accu…
Information processing and signal integration in bacterial quorum sensing
Pankaj Mehta, Sidhartha Goyal, Tao Long +2
Bacteria communicate using secreted chemical signaling molecules called autoinducers in a process known as quorum sensing. The quorum-sensing network of the marine bacterium {\it V…