9 papers · 1 filter
PerturbCellRL: Verifier-Guided Reinforcement Learning for Single-Cell Perturbation Prediction
Dongxia Wu, Mingyu Li, Yuhui Zhang +4
Single-cell perturbation models can reduce costly wet-lab screening by predicting how cells respond transcriptionally to interventions. While recent generative models improve popul…
CellFluxRL: Biologically-Constrained Virtual Cell Modeling via Reinforcement Learning
Dongxia Wu, Shiye Su, Yuhui Zhang +4
Building virtual cells with generative models to simulate cellular behavior in silico is emerging as a promising paradigm for accelerating drug discovery. However, prior image-base…
Uncertainty-Aware Distribution-to-Distribution Flow Matching for Scientific Imaging
Dongxia Wu, Yuhui Zhang, Serena Yeung-Levy +2
Distribution-to-distribution generative models support scientific imaging tasks ranging from modeling cellular perturbation responses to translating medical images across condition…
Functional-level Uncertainty Quantification for Calibrated Fine-tuning on LLMs
Ruijia Niu, Dongxia Wu, Rose Yu +1
Accurate uncertainty quantification in large language models (LLMs) is essential for reliable confidence estimation, yet fine-tuned LLMs often become overconfident under limited ad…
Divide and Learn: Multi-Objective Combinatorial Optimization at Scale
Esha Singh, Dongxia Wu, Chien-Yi Yang +3
Multi-objective combinatorial optimization seeks Pareto-optimal solutions over exponentially large discrete spaces, yet existing methods sacrifice generality, scalability, or theor…
Diffusion Models as Constrained Samplers for Optimization with Unknown Constraints
Lingkai Kong, Yuanqi Du, Wenhao Mu +8
Addressing real-world optimization problems becomes particularly challenging when analytic objective functions or constraints are unavailable. While numerous studies have addressed…