Verification, Validation, and Uncertainty Quantification (VVUQ) of Physiologically Based Pharmacokinetic Models for Theranostic Digital Twins: Towards Reliable Model-Informed Treatment Planning for Radiopharmaceutical Therapies

Nouran R. R. Zaid, Deni Hardiansyah, Tahir Yusufaly +1

Physiologically based pharmacokinetic (PBPK) models provide a mechanistic framework for simulating radiopharmaceutical kinetics and estimating patient-specific absorbed doses (ADs)…