3 papers
cs.CL2025
An Empirical Analysis of Fine-Tuning Large Language Models on Bioinformatics Literature: PRSGPT and BioStarsGPT
Muhammad Muneeb, David B. Ascher
Large language models (LLMs) often lack specialized knowledge for complex bioinformatics applications. We present a reproducible pipeline for fine-tuning LLMs on specialized bioinf…
cs.LG2024
Towards Evolutionary-based Automated Machine Learning for Small Molecule Pharmacokinetic Prediction
Alex G. C. de Sá, David B. Ascher
Machine learning (ML) is revolutionising drug discovery by expediting the prediction of small molecule properties essential for developing new drugs. These properties -- including…
q-bio.QM2023
AI driven B-cell Immunotherapy Design
Bruna Moreira da Silva, David B. Ascher, Nicholas Geard +1
Antibodies, a prominent class of approved biologics, play a crucial role in detecting foreign antigens. The effectiveness of antigen neutralisation and elimination hinges upon the…