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q-bio.QM2025
Multimodal Modeling of Ultradian Rhythms Using the Hankel Alternative View of Koopman (HAVOK) Analysis
Emmanuel Molefi, Billy C. Smith, Christopher Thornton +2
Ultradian rhythms - quasi-rhythmic fluctuations in behavior and physiology with periods shorter than 24 hours - are observed across various organisms, including humans. Despite the…
q-bio.NC2025
Dual mechanism of Anti-Seizure Medications in controlling seizure activity
Guillermo M. Besne, Emmanuel Molefi, Sarah J. Gascoigne +12
Background: Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by…
q-bio.NC2025
More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors
Billy C. Smith, Christopher Thornton, Rachel E. Stirling +7
Objective: The circadian rhythm synchronizes physiological and behavioural patterns with the 24-hour light-dark cycle. Disruption to the circadian rhythm is linked to various healt…