855 citations · 2.9k across the 86 of their papers we have counts for
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Somatic mutations render human exome and pathogen DNA more similar
Ehsan Ebrahimzadeh, Maggie Engler, David Tse +2
Immunotherapy has recently shown important clinical successes in a substantial number of oncology indications. Additionally, the tumor somatic mutation load has been shown to assoc…
Near-optimal Assembly for Shotgun Sequencing with Noisy Reads
Ka-Kit Lam, Asif Khalak, David Tse
Recent work identified the fundamental limits on the information requirements in terms of read length and coverage depth required for successful de novo genome reconstruction from…
Optimal Assembly for High Throughput Shotgun Sequencing
Guy Bresler, Ma'ayan Bresler, David Tse
We present a framework for the design of optimal assembly algorithms for shotgun sequencing under the criterion of complete reconstruction. We derive a lower bound on the read leng…