94 citations · 278 across the 7 of their papers we have counts for
7 papers
Twirling of actin by myosins II and V observed via polarized TIRF in a modified gliding assay
John F. Beausang, Harry W. Schroeder, Philip C. Nelson +1
The force generated between actin and myosin acts predominantly along the direction of the actin filament, resulting in relative sliding of the thick and thin filaments in muscle o…
Calibration of Tethered Particle Motion Experiments
L. Han, B. Lui, S. Blumberg +3
The Tethered Particle Motion (TPM) method has been used to observe and characterize a variety of protein-DNA interactions including DNA looping and transcription. TPM experiments e…
Concentration and Length Dependence of DNA Looping in Transcriptional Regulation
Lin Han, Hernan G. Garcia, Seth Blumberg +4
In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest. This acti…
First-principles calculation of DNA looping in tethered particle experiments
Kevin B. Towles, John F. Beausang, Hernan G. Garcia +2
We calculate the probability of DNA loop formation mediated by regulatory proteins such as Lac repressor (LacI), using a mathematical model of DNA elasticity. Our model is adapted…
Diffusive hidden Markov model characterization of DNA looping dynamics in tethered particle experiments
John F Beausang, Philip C Nelson
In many biochemical processes, proteins bound to DNA at distant sites are brought into close proximity by loops in the underlying DNA. For example, the function of some gene-regula…
DNA Looping Kinetics Analyzed Using Diffusive Hidden Markov Model
John F. Beausang, Chiara Zurla, Carlo Manzo +3
Tethered particle experiments use light microscopy to measure the position of a micrometer-sized bead tethered to a microscope slide via a ~micrometer length polymer, in order to i…