438 citations · 1.4k across the 20 of their papers we have counts for
7 papers · 1 filter
A phase field approach to trabecular bone remodeling
S. Aland, F. Stenger, R. Müller +6
We introduce a continuous modeling approach which combines elastic responds of the trabecular bone structure, the concentration of signaling molecules within the bone and a mechani…
Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
Katrin Talkenberger, Elisabetta Ada Cavalcanti-Adamda, Andreas Deutsch +1
During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the sw…
Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights
J. C. L. Alfonso, A. Kohn-Luque, T. Stylianopoulos +3
There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve functional tumou…
Emerging Allee effect in tumor growth
Katrin Böttger, Haralambos Hatzikirou, Anja Voss-Boehme +2
Tumor cells develop different features to adapt to environmental conditions. A prominent example is the ability of tumor cells to switch between migratory and proliferative phenoty…
A Game Theoretical Perspective on the Somatic Evolution of Cancer
David Basanta, Andreas Deutsch
Environmental and genetic mutations can transform the cells in a co-operating healthy tissue into an ecosystem of individualistic tumour cells that compete for space and resources.…
Evolutionary game theory elucidates the role of glycolysis in glioma progression and invasion
David Basanta, Matthias Simon, Haralambos Hatzikirou +1
Tumour progression has been described as a sequence of traits or phenotypes that cells have to acquire if the neoplasm is to become an invasive and malignant cancer. Although the g…
Studying the emergence of invasiveness in tumours using game theory
David Basanta, Haralambos Hatzikirou, Andreas Deutsch
Tumour cells have to acquire a number of capabilities if a neoplasm is to become a cancer. One of these key capabilities is increased motility which is needed for invasion of other…